Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer death in the United States. Lethality of PDA owes largely to the advanced disease stage at the time of diagnosis and to its profound resistance to existing therapies. Targeted therapy is a cornerstone of precision medicine, and is currently the focus of much anticancer drug development. However, in the context of pancreatic cancer, no chemical inhibitors exist for the most common KRAS mutations (G12D, G12V) even though it is well established that the oncogenic KRAS promotes drug resistance. Thus, a detailed understanding of the role of specific genetic lesions and their signaling surrogates in the initiation and progression of PDA is critical to improving treatment efficacy and patient outcome for this disease.

Our goal is to utilize sophisticated genetically engineered mouse models and ex vivo culture systems to understand the basic mechanisms underlying PDA biology such that vulnerabilities can be identified and tested for therapeutic intervention. 

 

Pancreatic ductal organoids-- An ex-vivo 3D culture platform that we use to interrogate biological dependencies in PDA

Pancreatic ductal organoids-- An ex-vivo 3D culture platform that we use to interrogate biological dependencies in PDA

Mass spectrometric approaches are used to probe oxidative post-translational modifications of the cysteine proteome and its implications in the growth and development of pancreatic cancer

Mass spectrometric approaches are used to probe oxidative post-translational modifications of the cysteine proteome and its implications in the growth and development of pancreatic cancer

Organoid-stromal cell co-cultures to probe redox-dependent cancer-tumor microenvironment interactions

Organoid-stromal cell co-cultures to probe redox-dependent cancer-tumor microenvironment interactions

In vivo model systems (autochthonous and organoid transplant mouse models) are used to probe the therapeutic relevance of different intervention strategies.

In vivo model systems (autochthonous and organoid transplant mouse models) are used to probe the therapeutic relevance of different intervention strategies.

© Copyright 2017-2018 by Christine Chio Lab. All Rights Reserved.

© Copyright 2017-2018 by Christine Chio Lab. All Rights Reserved.