Selected Publications
Nam JS, Dixon MS, Chio II. Hydrogen Sulfide: A Whiff of Trouble in Cancer Cell Survival. Molecular Cell. 2024. In Press
Singhal A, Styers H, Rub J, Li Z, Torborg S, Kim J, Heuzo O, Feng H, Tarcan Z, Sahin H, Hallin J, Basturk O, Yaeger R, Christensen J, Betel D, Yan Y, Chio II, DeStandchina E, Tammela T. A Classical epithelial state drives resistance to KRAS inhibition in Pancreas Cancer. 2024. Cancer Discovery.
Ross A, Pereira M, Ghore D, Kim J, Chio II*, Jovanovic M*. Systematic analysis of proteome turnover in pancreatic cancer. Cell Reports Methods. 2024;10;4(5):100760. *Co-correspondence
Boutin, R; Lee, H; Guan, T; Nguyen, T; Huang, X ; Waller, D; Lu, J; Chio, II; Michel, R; Sebag, M; Tsantrizos, Y. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate (C6-PyraP-BP) Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase (hGGPPS) and Evaluation of their Antitumor Efficacy in Multiple Myeloma (MM), Pancreatic Ductal Adenocarcinoma (PDAC) and Colorectal Cancer (CRC). Journal of Medicinal Chemistry. 2023; 66(23): 15776-15800.
DeBlasi J, Falzone A, Caldwell S, Kang YP, Prieto-Farigua N, Prigge J, Schmidt E, Chio II, Karreth F and DeNicola G. Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research. 2023; CAN-22-3848.
Saeki K, Qiu W, Friedman R, Pan S, Lu J, Ichimiya S, Chio II, Shawbwe C, Kitajewski J, Hu J, Su G. Inactivation of Notch4 attenuated pancreatic tumorigenesis in mice. Cancer Research Communications. 2022; 22-0106.
Powers, J Chio II. Softening Redox Homeostasis in Cancer. Nature Cell Biology. 2022. 24, pages 133–134
Zhou R, Xu J, Martin T, Ozturk S, Zachem A, He J, Demircioglu D, Bansal A, Trotta A, Giotti B, Gryder B, Yao S, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones D, Asara J, Chipuk J, Brody R, Itzkowitz S, Chio II, Hasson D, Bernstein E, and Parsons R. A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma Nature Communications. 2022; 13:604.
He D, Feng H, Sundberg B, Yang J, Powers J, Christian A, Wilkinson J, Mommin C, Avizonis D, Thomas C, Friedman R, Kluger M, Hollingsworth M, Grandgenett, P, Klute K, Toste D, Chang C, Chio II. Methionine Oxidation Activates Pyruvate Kinase M2 to Promote Pancreatic Cancer Metastasis. Molecular Cell. 2022; 82 (16):3045-60.
Yang, X, Chio II. PDA got SERious Nerves. Trends in Cancer. 2020
Chan KM, Robert F, Oertlin C, Kapeller-Libermann, D, Avizonis D, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Thomas C, Brown L, Porco J, Doubrovin M, Pollak M, Larsson O, Pelletier J, Chio II. eIF4A-dependent translational control of central carbon metabolism in pancreatic ductal adenocarcinoma. Nature Communications. 2019; 10, 5151
Ayres Pereira M, Chio II. Metastasis in Pancreatic Cancer: advances in the field and methodologies. Genes. 2019; 11 (1), 6
Tonelli C, Chio II, Tuveson DA. Transcriptional regulation by Nrf2. Antioxidants & redox signaling. 2018; 29 (17):1727-1745.
Chio II, Tuveson DA. ROS in Cancer: The Burning Question. Trends in Molecular Medicine. 2017; 23(5):411-429
Chio, II, Tuveson DA. ROS in translation: chink in the armor. Cell cycle. 2016
Chio, II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Ohlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016;166(4):963-76.
Boj SF*, Hwang CI*, Baker LA*, Chio, II*, Engle DD*, Corbo V*, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Ohlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160(1-2):324-38.
*Authors contributed equally to work.
Chio, II, Yordanov G, Tuveson D. MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors. JNCI. 2014;106(12).
Chio, II, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, Inoue S, Chang YL, Chen NJ, Mak TW. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol.2012;14(6):625-33.
Chen NJ*, Chio, II*, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zuniga-Pflucker JC, Wakeham A, Yeh WC, Mak TW. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A. 2008;105(34):12429-34. *Authors contributed equally to work
Ponz-Sarvise M, Corbo V, Tiriac H, Engle D, Freze K, Oni T, Hwang C, Ohlund D, Chio II, Baker L, Filippini D, Wright K, Barpiro T, Huang P, Smith P, Yu K, Jodrell D, Park Y and Tuveson D. Identification of resistance pathways specific to malignancy using organoid models of pancreatic cancer. Clinical Cancer research. 2019
Froeling F, Chio II, Li J Li A, Rogoff H, Tuveson D, Watson J. Bioactivation of napabucasin triggers reactive oxygen species–mediated killing of cancer cells. Clinical Cancer Research. 2019; 25(23);7162-7174
Liberti MV, Dai Z, Wardell S, Baccile J, Liu XJ, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio II, Tuveson D, Elemento O, Rathmell JC, Schroeder FC, McDonnell D and Locasale J.Selective targeting of the Warburge ffect and precision medicine from metabolic control analysis. Cell Metabolism. 2017. Cell metabolism. 2017; 26(4):648-659
Ohlund D, Handly-Santana A, Biffi G, Elyada E, Aameida A, Ponz-Sarvise M, Corbo V, Oni T, Hearn S, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker L, Engle D, Egeblad M, Fearon D, Crawford J, Clevers H, Park Y, Tuveson D. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. 2017. 2017; 214(3):579-596
Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio, II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016;19(2):205-16.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio, II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015;350(6266):1391-6.
Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio, II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 2015;22(11):1837-45.
Naguib A, Bencze G, Engle DD, Chio, II, Herzka T, Watrud K, Bencze S, Tuveson DA, Pappin DJ, Trotman LC. p53 mutations change phosphatidylinositol acyl chain composition. Cell Reports. 2015;10(1):8-19.
Chang YL, Chen TH, Wu YH, Chen GA, Weng TH, Tseng PH, Hsieh SL, Fu SL, Lin CH, Chen CJ, Chu CL, Chio, II, Mak TW, Chen NJ. A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction. J Cell Mol Med. 2014;18(7):1344-57.
Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio, II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev. 2013;27(10):1101-14.
Berger T, Ueda T, Arpaia E, Chio, II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene. 2013;32(41):4989-94.
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio, II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev.2012;26(18):2038-49.
Lin WJ, Su YW, Lu YC, Hao Z, Chio, II, Chen NJ, Brustle A, Li WY, Mak TW. Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFkappaB2 signaling that contributes to autoimmunity. Proc Natl Acad Sci U S A. 2011;108(45):18354-9.
Ueda T, Sasaki M, Elia AJ, Chio, II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A. 2010;107(32):13984-90.