Selected Publications
Peer-Reviewed Research Publications
1. Schaffer BE, Nam NJ, Cohen R, Mesaros C, Myers R, Baxt L, Wellen K, Cantley L, Dephoure N, Snyder N, Chio IIC#, Blenis J#. A lysis-derived PMSF and orthovanadate oxidant defines a distinct cysteine-engagement profile. Cell Chemical Biology. In press. #Co-correspondence. Epub: https://authors.elsevier.com/c/1ni9i8jWWK2~Nm
2. Nam JS, Ahn SS, Shin Y, Vargas-Castillo A, Dixon MS, Ahmadi P, Schilling K, Zandkarimi F, Chen A, Yoon NA, Cullen H, Sun Y, Caffrey TC, Klute KA, Swanson BJ, Lu J, Pan S, Chen Y, Ichimiya S, Kim G, Genkinger JM, Sugahara K, Kluger MD, Grandgenett P, Hollingsworth MA, Berchowitz L, Ferrante AW Jr, Zeltser LM, Diano S, Chio IIC. An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia. Nature Cancer. 2026. Epub: https://www.nature.com/articles/s43018-026-01234-y. Highlighted in: Adipocyte methionine reduction promotes cancer cachexia. Nature Cancer. September 22, 2026 (https://www.nature.com/articles/s43018-026-01202-6)
3. Powers J, Wei L, Cheung JCT, Ahmadi P, Kobayashi H, Curiel-Garcia A, Kang S, Valenzuela E, Jovanovic M, Chavez A, Chio IIC. eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression. Cancer Research. 2026;86(16):3920–31.
4. Shin H, Dorrity TJ, Aruda J, Wiegand KA, Nam JS, Yang J, Jones AS, Gertie JA, Singh MK, Yin Y, He K, Sarker R, Soni RK, Suh Y, Chio IIC, Rouskin S, Chung H. ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms. Cell Reports. 2026;45(3):117026. doi:10.1016/j.celrep.2026.117026.
5. Kobayashi H, Ochiai Y, Arai J, Hata M, Wu F, Sunagawa M, Iida T, Baba T, Malagola E, Tanaka T, Jiang Z, White RA, Zhi X, Qian J, Waterbury QT, Tu R, Zheng B, Zeng Y, Zheng H, Zhang P, Li S, Zamechek LB, LaBella JS, Sugie T, Enomoto A, Eltzschig HK, Palermo CF, Chio IIC, Olive KP, Wang TC. Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1. Cancer Research. 2026;86(8):1883-1901. doi:10.1158/0008-5472.CAN-25-2243.
6. Ichimiya S, Ahn SS, Dixon M, O’Sullivan JP, DeVine LC, Chen A, Yamamoto T, Oda Y, Nakamura M, Chio IIC. Dual Role of NRF2 in Pancreatic Precursor Lesions. Cancer Research Communications. 2025;5(6):945-959. doi:10.1158/2767-9764.CRC-25-0107.
7. Gallitto M, Zhang X, De Los Santos G, Wei HJ, Fernández EC, Sedor G, Yoh N, Kokossis D, Angel JC, Wang YF, Kinslow CJ, Chio IIC, Bruce JN, Feldstein NA, Cheng SK, Garvin JH, Wechsler-Reya RJ, Pavisic J, Wu CC. Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma. Neuro-Oncology. 2025;27(3):795-810.
8. Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T. A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer. Cancer Discovery. 2024;14(11):2122-2134. doi:10.1158/2159-8290.CD-24-0740.
#9. Ross AB, Gorhe D, Kim JK, Hodapp S, DeVine L, Chan KM, Chio IIC#, Jovanovic M#, Ayres Pereira M#. Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods. 2024;4(5):100760. #Co-correspondence.
10. Boutin R, Lee H-F, Guan TL, Nguyen TT, Huang XF, Waller DD, Lu J, Chio IIC, Michel RP, Sebag M, Tsantrizos YS. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry. 2023;66(23):15776-15800. doi:10.1021/acs.jmedchem.3c01271.
11. DeBlasi JM, Falzone A, Caldwell S, Prieto-Farigua N, Prigge JR, Schmidt EE, Chio IIC, Karreth FA, DeNicola GM. Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research. 2023;83(12):1953-1967. doi:10.1158/0008-5472.CAN-22-3848.
12. He D, Feng H, Sundberg B, Yang J, Powers J, Christian AH, Wilkinson JE, Monnin C, Avizonis D, Thomas CJ, Friedman RA, Kluger MD, Hollingsworth MA, Grandgenett PM, Klute KA, Toste FD, Chang CJ, Chio IIC. Methionine Oxidation Activates Pyruvate Kinase M2 to Promote Pancreatic Cancer Metastasis. Molecular Cell. 2022;82(16):3045-3060.e11. doi:10.1016/j.molcel.2022.06.005.
13. Saeki K, Qiu W, Friedman RA, Pan S, Lu J, Ichimiya S, Chio IIC, Shawber CJ, Kitajewski J, Hu J, Su GH. Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice. Cancer Research Communications. 2022;2(12):1601-1616. doi:10.1158/2767-9764.CRC-22-0106.
14. Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE. A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Nature Communications. 2022;13(1):6041. doi:10.1038/s41467-022-33377-8.
15. Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 2019;10(1):5151. doi:10.1038/s41467-019-13086-5.
16. Ponz-Sarvise M, Corbo V, Tiriac H, Engle DD, Frese KK, Oni TE, Hwang CI, Öhlund D, Chio IIC, Baker LA, Filippini D, Wright K, Bapiro TE, Huang PS, Smith PD, Yu KH, Jodrell DI, Park Y, Tuveson DA. Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Clinical Cancer Research. 2019;25(22):6742-6755. doi:10.1158/1078-0432.CCR-19-1398.
17. Froeling FEM, Mosur Swamynathan M, Deschênes A, Chio IIC, Brosnan E, Yao MA, Alagesan P, Lucito MS, Li J, Chang AY, Trotman LC, Belleau P, Park Y, Rogoff HA, Watson JD, Tuveson DA. Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death. Clinical Cancer Research. 2019;25(23):7162-7174. doi:10.1158/1078-0432.CCR-19-0302.
18. Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metabolism. 2017;26(4):648-659.e8. doi:10.1016/j.cmet.2017.08.017.
19. Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio IIC, Hwang CI, Tiriac H, Baker LA, Engle DD, Feig C, Kultti A, Egeblad M, Fearon DT, Crawford JM, Clevers H, Park Y, Tuveson DA. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. Journal of Experimental Medicine. 2017;214(3):579-596. doi:10.1084/jem.20162024.
20. Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Ohlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016, 166: 963-976. Highlighted in: Tummala K, Kottakis F, Bardeesy N. NRF2: Translating the Redox Code. Trends in Mol. Med. 2016; 22(10):829-831. Dickson I. Pancreatic Cancer: A role for redox regulation in PDAC. Nat Rev Gastroenterol Hepatol. 2016; 13(9):498
21. Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIC, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015; 350: 1391-1396.
22. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio IIC, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death & Differentiation. 2015; 22: 1837-1845.
23. Naguib A, Bencze G, Engle DD, Chio IIC, Herzka T, Watrud K, Bencze S, Tuveson DA, Pappin DJ, Trotman LC. p53 mutations change phosphatidylinositol acyl chain composition. Cell Reports. 2015; 10: 8-19.
24. Boj SF†, Hwang CI†, Baker LA†, Chio IIC†, Engle DD†, Corbo V†, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Ohlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015, 160: 324-338. †Equal contributions. Highlighted in: Patman G. Pancreatic Cancer: From normal to metastases—a whole gamut of pancreatic organoids. Nat Rev Gastroenterol Hepatol. 2015; 12:61.
25. Chang YL, Chen TH, Wu YH, Chen GA, Weng TH, Tseng PH, Hsieh SL, Fu SL, Lin CH, Chen CJ, Chu CL, Chio IIC, Mak TW, Chen NJ. A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction. Journal of Cellular & Molecular Medicine. 2014; 18: 1344-1357.
26. Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio IIC, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes & Development. 2013; 27: 1101-1114.
27. Berger T, Ueda T, Arpaia E, Chio IIC, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene. 2013;32(41):4989-4994.
28. Chio IIC, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, Inoue S, Chang YL, Chen NJ, Mak TW. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nature Cell Biology. 2012,14: 625-633. Highlighted in: Andrianantoandro E. TRADD: Promoting Senescence from Within the Nucleus. Science Signaling. 2012; 5(228):161
29. Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio IIC, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes & Development. 2012; 26: 2038-2049.
30. Lin WJ, Su YW, Lu YC, Hao Z, Chio IIC, Chen NJ, Brustle A, Li WY, Mak TW. Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFkappaB2 signaling that contributes to autoimmunity. Proceedings of the National Academy of Sciences USA. 2011; 108: 18354-18359.
31. Ueda T, Sasaki M, Elia AJ, Chio IIC, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase-interacting kinases 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proceedings of the National Academy of Sciences USA. 2010;107(32):13984-13990.
32. Chen NJ†, Chio IIC†, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zuniga-Pflucker JC, Wakeham A, Yeh WC, Mak TW. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proceedings of the National Academy of Sciences USA. 2008, 105: 12429-12434. †Equal contributions.
Reviews, Chapters, Monographs, and Editorials
33. Nam JS, Chio IIC. Redox Metabolism in Pancreatic Cancer. Methods in Molecular Biology. Springer Nature. 2026. In press.
34. Nam JS, Dixon MS, Chio IIC. Hydrogen sulfide: A whiff of trouble for cancer cell survival. Molecular Cell. 2024;84(20):3865-3867. doi:10.1016/j.molcel.2024.09.027.
35. Powers JA, Chio IIC. Softening redox homeostasis in cancer cells. Nature Cell Biology. 2022;24(2):133-134. doi:10.1038/s41556-022-00845-8.
36. Yang X, Chio IIC. PDA Got SERious Nerves. Trends in Cancer. 2021;7(2):89-91. doi:10.1016/j.trecan.2020.12.004.
37. Ayres Pereira M, Chio IIC. Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies. Genes. 2020;11(1):6. doi:10.3390/genes11010006.
38. Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2. Antioxidants & Redox Signaling. 2018; 29: 1727-1745.
39. #Chio IIC, #Tuveson DA. ROS in Cancer: The Burning Question. Trends in Molecular Medicine. 2017; 23: 411-429. #Co-correspondence
40. Chio IIC, Tuveson DA. ROS in translation: chink in the armor. Cell Cycle. 2017; 16: 297-298.
41. Chio IIC, Yordanov G, Tuveson D. MAX-ing Out MYC: A Novel Small Molecule Inhibitor Against MYC-Dependent Tumors. Journal of the National Cancer Institute. 2014; 106(12):dju365.